Is Ibuprofen/Advil Bad for My Liver and Kidneys?
You should wonder if a medication you often take for pain is safe. There are some misconceptions about NSAIDS (ibuprofen, naproxen, Motrin, Advil) and some truths. How much can or should you take and is it bad for your liver or kidneys? Every week I’m asked this question. How much? For the treatment of mild to moderate pain, minor fever, and acute or chronic inflammatory conditions 200 mg to 400 mg of ibuprofen will work, and is comparable to 650 mg of acetaminophen (Tylenol) or aspirin. Generally taken every 6 to 8 hours, the maximum dose of NSAIDs per day is 2400 mg which is 12 over-the-counter tablets. Liver-safe: Ibuprofen and other NSAIDS rarely affect the liver. Unlike acetaminophen (Tylenol) most NSAIDs are absorbed completely and have negligible first-pass hepatic (liver) metabolism. In other words, the way NSAIDS are metabolized makes liver toxicity (hepatotoxicity) very rare. Estimates are that 1 in 100,000 NSAID prescriptions result in acute liver injury. Generally ...