VALO'S ARCHIVE

To be fair, Indica and Sativa can only really be used to describe the appearance of a plant. It says nothing about the possible effects, for multiple reasons. CCR : Some users describe the psychoactive effects of Cannabis indica and sativa as being distinctive, even opposite. But are they really? Beyond self-reports from users, is there any hard evidence for pharmacologically different species of Cannabis? Dr. Russo : There are biochemically distinct strains of Cannabis, but the sativa/indica distinction as commonly applied in the lay literature is total nonsense and an exercise in futility. One cannot in any way currently guess the biochemical content of a given Cannabis plant based on its height, branching, or leaf morphology . The degree of interbreeding/hybridization is such that only a biochemical assay tells a potential consumer or scientist what is really in the plant. It is essential that future commerce allows complete and accurate cannabinoid and terpenoid profiles ...

First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness. In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “ Sphingolipid Rheostat .” If endogenous ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death ( apoptosis ) is imminent. If ceramide is low, the cell is strong in its vitality. Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid. The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, ...

Marijuana is not the only way to activate your  cannabinoid  system.  There are more fundamental and gentle ways that help activate your  cannabinoid  system and bring you similar benefits. Top 13 Ways to Increase Cannabinoids Without Smoking Pot I don’t think it’s a coincidence that I respond well to every treatment that increases cannabinoid receptors. 1) Stress Reduction Emotional stress  decreases CB1 receptors ( R ), including social defeat stress ( R ). Prolonged exposure to elevated glucocorticoids (cortisol), such as those induced by chronic stress conditions, significantly reduces hippocampal CB1 receptors ( R ), leading to lower cannabinoid function. In fact, a recent study suggests that CB1 receptor deficiency may mimic the effects of chronic stress on emotional behavior ( R ). 2) Omega 6’s Anandamide, 2-AG, 2-AGE, and other endogenous cannabinoids are derived fr...