VALO'S ARCHIVE

First let’s look at what keeps cancer cells alive, then we will come back and examine how the cannabinoids CBD (cannabidiol) and THC (tetrahydrocannabinol) unravels cancer’s aliveness. In every cell there is a family of interconvertible sphingolipids that specifically manage the life and death of that cell. This profile of factors is called the “ Sphingolipid Rheostat .” If endogenous ceramide (a signaling metabolite of sphingosine-1-phosphate) is high, then cell death ( apoptosis ) is imminent. If ceramide is low, the cell is strong in its vitality. Very simply, when THC connects to the CB1 or CB2 cannabinoid receptor site on the cancer cell, it causes an increase in ceramide synthesis which drives cell death. A normal healthy cell does not produce ceramide in the presence of THC, thus is not affected by the cannabinoid. The cancer cell dies, not because of cytotoxic chemicals, but because of a tiny little shift in the mitochondria. Within most cells there is a cell nucleus, ...

The mechanism by which the conscious feeling of euphoria is felt is still unknown. Due to the multiple methods by which euphoria can occur it is likely a 'natural' state of the brain that can be triggered either naturally or unnaturally. It is also likely that it occurs in the same brain regions responsible for mood. https://en.wikipedia.org/wiki/Reward_system You'll note that many of the structures connected to the reward system are glutamatergic interneurons. This means that excess glutamate can trigger the reward system to produce euphoric feelings. In cerebral hypoxia the lack of oxygen results in a lack of energy for the cell. Mainly this results in the switching off of the sodium / potassium pump. A nerve cell fires by moving sodium outside the cell and potassium inside the cell to create concentration gradients, that are then reversed during an action potential. If the pump does not have oxygen then this mechanism stops. This results in an increase in e...